What are the Clinical Studies?
This clinical study was double-blind, randomized, against placebo. It was carried on 95 healthy female subjects, mean-aged 55,6 y.o, for 12 weeks. The objective was to evaluate the anti-aging potential of a daily oral intake of 2,5g of our fish collagen peptides on cutaneous measures and its tolerance. 2,5g of collagen powder was mixed with water and ingested in the morning. This study was conducted by CPCAD / Hospital of Nice (France) and biomechanical measurements of volunteers were controlled by certified dermatologists.
The clinical assessment of the perioral and Crow’s feet wrinkles compared with baseline showed a significant decrease of the mean score of facial wrinkles at week 12.
At Week 12, an improvement in crow’s feet wrinkles was observed for more than 70% of the subjects in the 2.5g/d collagen treated groups.
As well, about 60% of the subjects showed an improvement in perioral wrinkles in 2.5g/d collagen group.
This clinical study was performed according to French regulatory competent authority (ANSM) and approved by the local Ethical Committee (CPP). Consent was obtained from each subject before entry in the study.
At Week 12, an improvement in crow’s feet wrinkles was observed for more than 70% of the subjects in the 2.5g/d collagen treated groups. As well, about 60% of the subjects showed an improvement in perioral wrinkles in 2.5g/d collagen group.
The second study measures elasticity of two groups (one with our collagen, one without):
The Cutometer® DUAL probe (Courage and Kazhaka, Köln, Germany) using a suction method measured a deformation perpendicular to the skin surface. A negative pressure of 450 mbars was applied to the skin through the probe for 2 seconds, followed by a relaxation period of 2 seconds. This cycle was performed 5 times. This method measures the degree of deformation and the time required for the skin to return to its original state. The deformation induced on the skin is measured by an optical system.
A significant increase in skin firmness on the external part of the forearm was observed at Week 12 for 2,5g/d while no significant changes over time were observed in the placebo group.
The third study measures radiance in skin of two groups (one with our collagen, one without):
A visual analogic scale (VAS) was used by a trained clinician to assess the level of skin radiance between 0 (very dull skin) and 10 (very radiant skin). At the same manner, a visual analogic scale (VAS) was used to assess the level of skin complexion homogeneity between 0 (very heterogeneous complexion) and 10 (very homogeneous complexion).
Skin radiance and skin complexion homogeneity were statistically significantly increased for 2,5g/d after Week 8 while no significant change was seen in the Placebo group.
